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Epinephrine Reagent

Catalog No.:       101311

Net Contents:     3 x 0.5 mL

EPINEPHRINE REAGENT   Adrenaline

Epinephrine Reagent's Pivotal Role in Platelet Studies for Hypersensitivity and Sticky Platelet Syndrome Assessment

Epinephrine Reagent (Adrenaline) is for routine use in platelet studies for the evaluation of hypersensitivity of platelets in Platelet Rich Plasma and evaluation of platelet responses to a weak agonist.

  • Induces Platelet Aggregation and Serotonin Release

  • Produces Secondary Aggregation Wave when Alpha Granules Release ADP

  • Potentiates Aggregation by Other Agonists

  • Used in Testing for Sticky Platelet Syndrome

  • Does Not Induce Shape Change

TECHNICAL BULLETIN

PRODUCT DETAILS

Epinephrine Reagent, also known as Adrenaline, serves as a routine component in platelet studies, offering a valuable tool for assessing the hypersensitivity of platelets within Platelet Rich Plasma (PRP) and evaluating their responses to weak agonists. When introduced to platelet-rich plasma, Epinephrine plays a pivotal role in stimulating platelets, inducing what is commonly termed as primary aggregation.

This process triggers normal platelets to undergo further responses, leading to the release of endogenous ADP from alpha granules. The consequential release of endogenous ADP gives rise to a secondary aggregation wave, providing researchers with a comprehensive view of platelet behavior. The reagent's ability to produce this secondary aggregation wave is particularly noteworthy, shedding light on the intricate dynamics of platelet function.

Furthermore, Epinephrine Reagent has been identified as a potent facilitator of platelet aggregation by other agonists, thereby amplifying the overall understanding of platelet responses. This attribute enhances the versatility of Epinephrine Reagent in the field of platelet studies, enabling researchers to explore a wide range of scenarios and stimuli.

 

Moreover, the reagent finds practical application in the testing for Sticky Platelet Syndrome, offering a diagnostic tool for this particular platelet disorder. In the context of Sticky Platelet Syndrome testing, Epinephrine Reagent proves instrumental in unveiling distinctive platelet characteristics associated with this syndrome.
 

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Importantly, it's worth noting that Epinephrine Reagent does not induce shape change in platelets during the evaluation process. This unique characteristic adds another layer of precision to its application in platelet studies, allowing researchers to focus specifically on aggregation dynamics without confounding variables related to shape alterations.

Epinephrine Reagent emerges as a versatile and indispensable tool in platelet studies, contributing significantly to the understanding of hypersensitivity, platelet responses, and the intricate mechanisms involved in disorders such as Sticky Platelet Syndrome.

Please explore the provided documentation on this page, including the Epinephrine Reagent Product Data Sheet and Routine Agonist Expected Results Chart. Additionally, consult the Epinephrine Reagent Instruction for Use (IFU) and the Epinephrine Reagent Safety Data Sheet (SDS), both available in six languages. For our European and United Kingdom customers and distributors, thoroughly review the EU and UK Declaration of Conformity to ensure compliance and a nuanced understanding tailored for these specific regions. Acquiring this information is vital for obtaining a comprehensive understanding of the product details and specifications.

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