Catalog No.: 101562
Net Contents: 3 x 0.5 mL
COLLAGEN REAGENT Soluble Calf Skin, Type 1
Collagen Reagent (Soluble Calf Skin, Type 1) Unleashes Innovative Insights into Platelet Rich Plasma Responses
Collagen Reagent (Soluble Calf Skin, Type 1) is intended for routine use in inducing Platelet Rich Plasma responses to activation, aggregation and inhibition.
Displays LAG PHASE Prior to Platelet Shape Change
Acts as a Substrate for Platelet Adhesion
Induces Platelet Activation and Aggregation
Causes Integrin Activation via GP VI Receptor
Releases Thrombotic Substances
Generates TX A2
Collagen Reagent (Soluble Calf Skin, Type 1) serves as a pivotal tool in the realm of platelet research, offering a reliable methodology for inducing and studying Platelet Rich Plasma (PRP) responses encompassing activation, aggregation, and inhibition.
In the initial stages, upon the introduction of collagen to platelet-rich plasma, a lag phase is observed before a significant alteration in platelet shape occurs. This lag phase provides a crucial temporal window for researchers to closely observe and analyze the dynamic changes in platelet behavior.
Functioning as a substrate, the collagen reagent actively facilitates platelet adhesion, creating an essential foundation for subsequent biological processes. As platelets adhere to the collagen, a cascade of events is triggered, leading to their activation and subsequent aggregation. This orchestrated series of responses not only sheds light on fundamental platelet biology but also serves as a valuable tool for investigating potential therapeutic interventions related to platelet function.
Moreover, the collagen reagent plays a pivotal role in integrin activation through the GP VI receptor, further elucidating the molecular mechanisms involved in platelet responses. This in-depth understanding of integrin activation contributes to the broader comprehension of platelet physiology and its implications in various physiological and pathological conditions.
An additional facet of the collagen reagent's impact lies in its ability to release thrombotic substances, adding a layer of complexity to the study of platelet function. This capability broadens the scope of research, enabling scientists to explore the intricate interplay of molecular signals and substances involved in thrombosis.
Furthermore, the collagen reagent stands as a generator of TX A2, a biologically active substance with implications for platelet function. This specific generation adds a nuanced dimension to the study of platelet responses, allowing researchers to delve deeper into the signaling pathways and molecular players involved in the intricate balance of hemostasis and thrombosis.
In essence, the routine use of Collagen Reagent (Soluble Calf Skin, Type 1) not only induces a spectrum of platelet responses but also opens up new avenues for advancing our understanding of platelet biology and its relevance to health and disease.
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