ARACHIDONIC ACID Sodium Arachidonate
Catalog No. 101297
Arachidonic Acid (Sodium Arachidonate) Reagent is for routine use in demonstrating thromboxane A2 activation response in Platelet Rich Plasma samples.
Stimulates Platelets to Convert COX 1 Enzyme into TX A2
Demonstrates the Efficacy of TX A2 Platelet Activation Pathway
Shows the Increase in Microparticles and Activated Platelets in Response to
May cause Lysis of Red Blood Cells and Subsequent ADP-Dependent Platelet Activation Responses in Platelet Rich Plasma Samples
Arachidonic Acid is a fatty acid present in the granules and membranes of human platelets.
It is liberated from phospholipids and, in the presence of the enzyme cyclo-oxygenase, incorporates oxygen to form the endoperoxide prostaglandin G2 (PGG2). PGG2 is then quickly transformed to prostaglandin H2 (PGH2) which in turn is converted to thromboxane A2 a potent inducer of platelet aggregation. Ingestion of aspirin or aspirin-containing compounds inhibits cyclo-oxygenase mediated oxygen consumption, thus precluding all subsequent events leading to platelet aggregation.
Net Contents: 3 x 0.5 mL
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