ARACHIDONIC ACID Sodium Arachidonate
Catalog No. 101297
Arachidonic Acid (Sodium Arachidonate) Reagent is for routine use in demonstrating thromboxane A2 activation response in Platelet Rich Plasma samples.
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Stimulates Platelets to Convert COX 1 Enzyme into TX A2
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Demonstrates the Efficacy of TX A2 Platelet Activation Pathway
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Shows the Increase in Microparticles and Activated Platelets in Response to
Increasing Concentrations -
May cause Lysis of Red Blood Cells and Subsequent ADP-Dependent Platelet Activation Responses in Platelet Rich Plasma Samples
PRODUCT DETAILS
Arachidonic Acid is a fatty acid present in the granules and membranes of human platelets.
It is liberated from phospholipids and, in the presence of the enzyme cyclo-oxygenase, incorporates oxygen to form the endoperoxide prostaglandin G2 (PGG2). PGG2 is then quickly transformed to prostaglandin H2 (PGH2) which in turn is converted to thromboxane A2 a potent inducer of platelet aggregation. Ingestion of aspirin or aspirin-containing compounds inhibits cyclo-oxygenase mediated oxygen consumption, thus precluding all subsequent events leading to platelet aggregation.
Net Contents: 3 x 0.5 mL
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