AGGRECETIN® 100mg Ristocetin A Sulfate

AggRecetin® (Ristocetin) Reagent: Peak Platelet Precision with Over 90% Ristocetin Purity for Trusted RIPA Testing

AggRecetin® (Ristocetin) Reagent is intended for use in performing routine Ristocetin-Induced Platelet Aggregation (RIPA) testing on Platelet-Rich Plasma (PRP) samples to assess platelet function.

Optimized for RIPA Testing: Delivers reliable platelet aggregation results at both low and high Ristocetin concentrations.
Low-Dose RIPA Sensitivity: Facilitates detection of hyper-responsiveness in type 2B vWD and PT-vWD patients.
High-Dose RIPA Confirmation: Verifies normal platelet-vWF interaction or rules out qualitative defects in vWF.
Supports Targeted Guidelines: Aligns with international guidelines for vWD classification and platelet function evaluation.
Enables GPIb-vWF Binding Assessment: Reveals abnormalities in platelet receptor binding activity central to vWD pathology.

AggRecetin is Ristocetin A Sulfate, a glycopeptide of unknown chemical structure isolated from Nocardia lurida. AggRecetin contains more than 90% Ristocetin A.

AggRecetin (Ristocetin) Reagent has been optimized for use with Light Transmission Aggregometers. It may also be used with other turbidometric or impedance analyzers, and flow cytometers.

Explore Product Data Sheet

Kindly explore the materials provided on this page, including the AggRecetin Reagent Product Data Sheet, the AggRecetin Instruction for Use (IFU), and the AggRecetin Safety Data Sheet (SDS), available in seven languages. For our European and United Kingdom customers and distributors, carefully review the AggRecetin EU Declaration of Conformity and the AggRecetin UK Declaration of Conformity to ensure compliance and tailored understanding for these specific regions. This information is crucial for gaining a comprehensive understanding of the product details and specifications.

Bio/Data Corporation’s Aggregation Reagents: Accessible Safety Data Sheets for Secure Handling

Bio/Data Corporation provides comprehensive Safety Data Sheets (SDS) for each of its carefully formulated aggregation reagents. These essential documents ensure safe handling, storage, and spill management while offering clear instructions on potential hazards. Designed for easy viewing, saving, and printing, the SDS are readily accessible to support a safe work environment and responsible chemical management.

Access Safety Data Sheet

Product Function

AggRecetin (Ristocetin) Reagent provides insight into different aspects of platelet function / quality. This Reagent aids in accessing various acquired and inherited platelet disorders or the efficacy of anti-platelet therapies.

Review Instructions For Use

Specific Information Provided
AggRecetin (Ristocetin) Reagent is not intended for the detection of a specific disorder, condition, or risk factor.

AggRecetin (Ristocetin) Reagent is a distinctive platelet reagent employed in the realm of Ristocetin Induced Platelet Aggregation (RIPA) testing. Ristocetin interacts with von Willebrand Factor (vWF), a critical plasma protein involved in platelet adhesion and aggregation processes. Ristocetin prompts a conformational shift in vWF, exposing binding sites for platelet glycoprotein Ib (GP Ib). Consequently, platelet GP Ib receptors engage with vWF, initiating platelet adhesion. This initial adherence primes platelets for aggregation. In instances lacking von Willebrand Factor (vWF) or related platelet function disorders, Ristocetin Induced Platelet Aggregation proceeds to a limited extent due to platelets’ incapacity to aggregate effectively. Consequently, RIPA testing furnishes invaluable insights into platelet function / quality and vWF activity, thereby aiding in the characterization of von Willebrand Disease (vWD) and associated bleeding disorders. This testing method plays a vital role in evaluating platelet function / quality accurately.

Automation
AggRecetin (Ristocetin) Reagent is intended for use in semi-automated and automated Light Transmission Platelet Aggregometers. This reagent may also be used with other turbidometric or impedance analyzers, and flow cytometers.

Quality / Quantity
There are no primary standards for the AggRecetin (Ristocetin) Reagent. The responses to these reagents are concentration dependent. A known normal donor should be tested with each new lot of AggRecetin (Ristocetin) Reagent. Standards organizations classify Ristocetin induced platelet aggregation (RIPA) as semi-quantitative or semi-qualitative.

AggRecetin (Ristocetin) Reagent packaged as 1 x 15 mg vial, including 1 x 2.0 mL Diluent, or 1 x 100 mg. The working concentration of AggRecetin is 15 mg / mL.

Specimen Type
The test specimen is prepared from sodium citrate anti-coagulated whole blood. The test sample is Platelet Rich Plasma (PRP). The test blank is Platelet Poor Plasma (PPP).

AggRecetin (Ristocetin) Reagent may be used with human or animal Platelet Rich Plasma (PRP) for routine platelet aggregation tests.. Results are based on the concentration, extent, and rate of aggregation compared to a Platelet Poor Plasma (PPP) blank.

In Vitro Diagnositc
AggRecetin (Ristocetin) Reagent is an in vitro diagnostic reagent intended for Professional Laboratory Use Only. This Reagent is not intended for injection or ingestion.

Test Principle
When introduced to a stirred, 37°C Platelet Rich Plasma (PRP) test sample, exogenous Reagents such as AggRecetin (Ristocetin) stimulate platelets, prompting them to undergo shape change and aggregate. This initial aggregation is called primary aggregation and is reversible. However, normal platelets possess the ability to release endogenous ADP from their granules, leading to a secondary, irreversible wave of aggregation. The Light Transmission Platelet Aggregometer effectively captures these changes by displaying parameters such as lag phase, shape change, and the rate and extent of aggregation over a predetermined testing period.

READ MORE... Easily Download the AggRecetin Reagent Instructions for Use in Your Selected Language.

Reagents Provided

AggRecetin (Ristocetin) Reagent, 100 mg

Reagents and Materials Required but Not Provided

Purified Water (Distilled, Deionized, Reagent Grade), pH 5.3 – 7.2 for reconstitution
TRIS Buffered Saline (TBS) or 0.85% physiologic saline for dilutions

NOTE: USING BLOOD BANK SALINE WILL CAUSE ERRONEOUS RESULTS.

Materials and Accessories

Platelet Aggregometer
Centrifuge
Electronic Pipette
Pipette Tips
Aggregometer Test Tubes (Siliconized)
Aggregometer Stir Bars (Plastic Coated)
Plastic Sample Tubes and Caps (For Dilutions)

Reagent Storage

AggRecetin (Ristocetin) Reagent does not require temperature protection during shipment.
Upon receipt, store AggRecetin (Ristocetin) Reagent at 2 – 8° C in its original packaging.
Reconstituted AggRecetin (Ristocetin) Reagent is stable for 7 days when stored in its’ tightly capped, original container at 2 – 8° C.

AggRecetin Ristocetin Aggregation Reagent

AGGRECETIN IS AVAILABLE

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Bio/Data Corporation's Commitment to IVDR Compliance
Bio/Data Corporation proudly complies with the stringent EU In Vitro Diagnostic Regulation (IVDR) 2017/746 and other relevant legislation. Through its Declaration of Conformity (DOC), the company ensures that its devices meet essential health, safety, and environmental standards.

Bio/Data Corporation's Commitment to UKCA Compliance
Bio/Data Corporation ensures product excellence by strictly adhering to UKCA regulations. The company's Declaration of Conformity (DOC) affirms its dedication to meeting health, safety, and environmental standards outlined in UKCA directives and any related updates, demonstrating its unwavering commitment to compliance.

View EU Declaration of Conformity

View UK Declaration of Conformity

AGGRECETIN® 100mg Ristocetin A Sulfate

AggRecetin® (Ristocetin) Reagent: Peak Platelet Precision with Over 90% Ristocetin Purity for Trusted RIPA Testing

AggRecetin® (Ristocetin) Reagent is intended for use in performing routine Ristocetin-Induced Platelet Aggregation (RIPA) testing on Platelet-Rich Plasma (PRP) samples to assess platelet function.

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