Catalog No.: 107462
Net Contents: 1.0 mg
U-46619 TX A2 Stable Synthetic Analog
U-46619 TX A2: Advancing Platelet Activation Science with Stable Synthetic Analog
U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to Thromboxane A2 (TX A2).
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Activates TP Receptor
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Controls Positive Feedback in Activation and Recruitment of Platelets
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Enhances Aggregation by way of other GPCR Receptors
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Stimulates AA / TX A2 Production and ADP Secretion
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Works on Multiple Species
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Induces Acute Pulmonary Hypertension in Animal Models
TECHNICAL BULLETIN
PRODUCT DETAILS
U-46619 TX A2 Stable Synthetic Analog is a stable analog derived from the endoperoxide prostaglandin H2, functioning as a TP receptor agonist and exhibiting properties reminiscent of Thromboxane A2 (TX A2).
This synthetic analog initiates TP receptor activation, leading to responses within platelets. It also regulates positive feedback mechanisms, exerting influence on platelet activation and recruitment. Furthermore, U-46619 enhances aggregation not only through TP receptor activation but also by engaging other G protein-coupled receptors (GPCRs).
Stimulating arachidonic acid (AA) and Thromboxane A2 (TX A2) production, U-46619 contributes to platelet activation and ADP secretion. Notably, its effectiveness extends across multiple species, making it a versatile tool for research in various biological contexts. In animal models, U-46619 demonstrates its impact by inducing acute pulmonary hypertension.
Physiologically, U-46619 induces platelet shape change, aggregation, and vascular smooth muscle contraction. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM, respectively. For platelet aggregation, these values are 82, 145, and 65 nM, respectively.
The mechanisms of action involve ADP release from platelet-dense granules, with polymorphonuclear leukocytes potentially acting as anti-aggregatory agents in U-46619-induced platelet aggregation.
Each unit of U-46619 TX A2 Stable Synthetic Analog contains a net content of 1.0 mg, emphasizing its multifaceted nature and value for researchers exploring platelet biology, thrombosis, and cardiovascular physiology.
Carefully explore the provided materials, specifically the U-46619 TX A2 Product Data Sheet. Furthermore, refer to the U-46619 TX A2 Instruction for Use (IFU) and the U-46619 TX A2 Safety Data Sheet (SDS), both provided in six languages. To comprehend the product's details and specifications comprehensively, a diligent review of this information is necessary.
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