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U-46619   TX A2 Stable Synthetic Analog

Catalog No.  107462

U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to Thromboxane A2 (TX A2).

 

  • Activates TP Receptor

  • Controls Positive Feedback in Activation and Recruitment of Platelets

  • Enhances Aggregation by way of other GPCR Receptors

  • Stimulates AA / TX A2 Production and ADP Secretion

  • Works on Multiple Species

  • Induces Acute Pulmonary Hypertension in Animal Models

TECHNICAL BULLETIN

PRODUCT DETAILS

U-46619 causes platelet shape change and aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for platelet aggregation are 82, 145, and 65 nM, respectively.

let activation by U-46619 is mediated largely by ADP released from platelet-dense granules. Polymorphonuclear leukocytes may function as anti-aggregatory agents in platelet aggregation induced by U-46619.

Net Contents:   1.0 mg

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